Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer

Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an execut...

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Detalles Bibliográficos
Autores principales: Zhao, Ran, Choi, Bu Young, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919535/
https://www.ncbi.nlm.nih.gov/pubmed/27428416
http://dx.doi.org/10.1016/j.ebiom.2016.04.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919535/
https://www.ncbi.nlm.nih.gov/pubmed/27428416
http://dx.doi.org/10.1016/j.ebiom.2016.04.017

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