Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer

Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an execut...

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Detalles Bibliográficos
Autores principales: Zhao, Ran, Choi, Bu Young, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919535/
https://www.ncbi.nlm.nih.gov/pubmed/27428416
http://dx.doi.org/10.1016/j.ebiom.2016.04.017
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author Zhao, Ran
Choi, Bu Young
Lee, Mee-Hyun
Bode, Ann M.
Dong, Zigang
author_facet Zhao, Ran
Choi, Bu Young
Lee, Mee-Hyun
Bode, Ann M.
Dong, Zigang
author_sort Zhao, Ran
collection PubMed
description Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an executional role in cell cycle and senescence through the regulation of the cyclin-dependent kinase (CDK) 4/6 and cyclin D complexes. Several genetic and epigenetic aberrations of CDKN2A lead to enhanced tumorigenesis and metastasis with recurrence of cancer and poor prognosis. In these cases, the restoration of genetic and epigenetic reactivation of CDKN2A is a practical approach for the prevention and therapy of cancer. This review highlights the genetic status of CDKN2A as a prognostic and predictive biomarker in various cancers.
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spelling pubmed-49195352016-06-30 Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer Zhao, Ran Choi, Bu Young Lee, Mee-Hyun Bode, Ann M. Dong, Zigang EBioMedicine Review Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an executional role in cell cycle and senescence through the regulation of the cyclin-dependent kinase (CDK) 4/6 and cyclin D complexes. Several genetic and epigenetic aberrations of CDKN2A lead to enhanced tumorigenesis and metastasis with recurrence of cancer and poor prognosis. In these cases, the restoration of genetic and epigenetic reactivation of CDKN2A is a practical approach for the prevention and therapy of cancer. This review highlights the genetic status of CDKN2A as a prognostic and predictive biomarker in various cancers. Elsevier 2016-05-03 /pmc/articles/PMC4919535/ /pubmed/27428416 http://dx.doi.org/10.1016/j.ebiom.2016.04.017 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhao, Ran
Choi, Bu Young
Lee, Mee-Hyun
Bode, Ann M.
Dong, Zigang
Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
title Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
title_full Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
title_fullStr Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
title_full_unstemmed Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
title_short Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
title_sort implications of genetic and epigenetic alterations of cdkn2a (p16(ink4a)) in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919535/
https://www.ncbi.nlm.nih.gov/pubmed/27428416
http://dx.doi.org/10.1016/j.ebiom.2016.04.017
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