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Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an execut...
Autores principales: | Zhao, Ran, Choi, Bu Young, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919535/ https://www.ncbi.nlm.nih.gov/pubmed/27428416 http://dx.doi.org/10.1016/j.ebiom.2016.04.017 |
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