STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism

START domain proteins are conserved α/β helix-grip fold that play a role in the non-vesicular and intracellular transport of lipids and sterols. The mechanism and conformational changes permitting the entry of the ligand into their buried binding sites is not well understood. Moreover, their functio...

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Detalles Bibliográficos
Autores principales: Létourneau, Danny, Bédard, Mikaël, Cabana, Jérôme, Lefebvre, Andrée, LeHoux, Jean-Guy, Lavigne, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919784/
https://www.ncbi.nlm.nih.gov/pubmed/27340016
http://dx.doi.org/10.1038/srep28486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919784/
https://www.ncbi.nlm.nih.gov/pubmed/27340016
http://dx.doi.org/10.1038/srep28486

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