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STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism
START domain proteins are conserved α/β helix-grip fold that play a role in the non-vesicular and intracellular transport of lipids and sterols. The mechanism and conformational changes permitting the entry of the ligand into their buried binding sites is not well understood. Moreover, their functio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919784/ https://www.ncbi.nlm.nih.gov/pubmed/27340016 http://dx.doi.org/10.1038/srep28486 |