HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma

BACKGROUND: Histone deacetylation, a common hallmark in malignant tumors, strongly alters the transcription of genes involved in the control of proliferation, cell survival, differentiation and genetic stability. We have previously shown that HDAC1, HDAC2, and HDAC3 (HDAC1–3) genes encoding histone...

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Detalles Bibliográficos
Autores principales: Buurman, Reena, Sandbothe, Maria, Schlegelberger, Brigitte, Skawran, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919854/
https://www.ncbi.nlm.nih.gov/pubmed/27342975
http://dx.doi.org/10.1186/s40001-016-0217-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919854/
https://www.ncbi.nlm.nih.gov/pubmed/27342975
http://dx.doi.org/10.1186/s40001-016-0217-x

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