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HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma
BACKGROUND: Histone deacetylation, a common hallmark in malignant tumors, strongly alters the transcription of genes involved in the control of proliferation, cell survival, differentiation and genetic stability. We have previously shown that HDAC1, HDAC2, and HDAC3 (HDAC1–3) genes encoding histone...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919854/ https://www.ncbi.nlm.nih.gov/pubmed/27342975 http://dx.doi.org/10.1186/s40001-016-0217-x |