Structural transitions in full-length human prion protein detected by xenon as probe and spin labeling of the N-terminal domain

Fatal neurodegenerative disorders termed transmissible spongiform encephalopathies (TSEs) are associated with the accumulation of fibrils of misfolded prion protein PrP. The noble gas xenon accommodates into four transiently enlarged hydrophobic cavities located in the well-folded core of human PrP(...

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Detalles Bibliográficos
Autores principales: Narayanan, Sunilkumar Puthenpurackal, Nair, Divya Gopalakrishnan, Schaal, Daniel, Barbosa de Aguiar, Marisa, Wenzel, Sabine, Kremer, Werner, Schwarzinger, Stephan, Kalbitzer, Hans Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920026/
https://www.ncbi.nlm.nih.gov/pubmed/27341298
http://dx.doi.org/10.1038/srep28419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920026/
https://www.ncbi.nlm.nih.gov/pubmed/27341298
http://dx.doi.org/10.1038/srep28419

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