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Conditioning adaptive combination of P-values method to analyze case-parent trios with or without population controls
Detection of rare causal variants can help uncover the etiology of complex diseases. Recruiting case-parent trios is a popular study design in family-based studies. If researchers can obtain data from population controls, utilizing them in trio analyses can improve the power of methods. The transmis...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920030/ https://www.ncbi.nlm.nih.gov/pubmed/27341039 http://dx.doi.org/10.1038/srep28389 |