2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration

The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neur...

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Autores principales: Tillo, Miguel, Charoy, Camille, Schwarz, Quenten, Maden, Charlotte H., Davidson, Kathryn, Fantin, Alessandro, Ruhrberg, Christiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920156/
https://www.ncbi.nlm.nih.gov/pubmed/27048738
http://dx.doi.org/10.1242/dev.126854
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author Tillo, Miguel
Charoy, Camille
Schwarz, Quenten
Maden, Charlotte H.
Davidson, Kathryn
Fantin, Alessandro
Ruhrberg, Christiana
author_facet Tillo, Miguel
Charoy, Camille
Schwarz, Quenten
Maden, Charlotte H.
Davidson, Kathryn
Fantin, Alessandro
Ruhrberg, Christiana
author_sort Tillo, Miguel
collection PubMed
description The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neuronal migration and axon development. We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST (also known as HS2ST1) is important to regulate the migration of facial branchiomotor (FBM) neurons in the hindbrain. We have also investigated how HS2ST interacts with other signals in the hindbrain and show that fibroblast growth factor (FGF) signalling regulates FBM neuron migration in an HS2ST-dependent manner.
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spelling pubmed-49201562016-07-25 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration Tillo, Miguel Charoy, Camille Schwarz, Quenten Maden, Charlotte H. Davidson, Kathryn Fantin, Alessandro Ruhrberg, Christiana Development Research Report The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neuronal migration and axon development. We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST (also known as HS2ST1) is important to regulate the migration of facial branchiomotor (FBM) neurons in the hindbrain. We have also investigated how HS2ST interacts with other signals in the hindbrain and show that fibroblast growth factor (FGF) signalling regulates FBM neuron migration in an HS2ST-dependent manner. The Company of Biologists Ltd 2016-06-01 /pmc/articles/PMC4920156/ /pubmed/27048738 http://dx.doi.org/10.1242/dev.126854 Text en © 2016. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Report
Tillo, Miguel
Charoy, Camille
Schwarz, Quenten
Maden, Charlotte H.
Davidson, Kathryn
Fantin, Alessandro
Ruhrberg, Christiana
2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
title 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
title_full 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
title_fullStr 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
title_full_unstemmed 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
title_short 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
title_sort 2- and 6-o-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920156/
https://www.ncbi.nlm.nih.gov/pubmed/27048738
http://dx.doi.org/10.1242/dev.126854
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