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De novo actin polymerization is required for model Hirano body formation in Dictyostelium

Hirano bodies are eosinophilic, actin-rich inclusions found in autopsied brains in numerous neurodegenerative diseases. The mechanism of Hirano body formation is unknown. Mass spectrometry analysis was performed to identify proteins from partially purified model Hirano bodies from Dictyostelium. Thi...

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Detalles Bibliográficos
Autores principales: Dong, Yun, Shahid-Salles, Sonbol, Sherling, Dan, Fechheimer, Nathan, Iyer, Nathan, Wells, Lance, Fechheimer, Marcus, Furukawa, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920178/
https://www.ncbi.nlm.nih.gov/pubmed/27215322
http://dx.doi.org/10.1242/bio.014944