Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8(+)CD11c(+) PD-1(lo) Effector T Cells

Natural regulatory T (Treg) cells interfere with multiple functions, which are crucial for the development of strong anti-tumour responses. In a model of 4T1 mammary carcinoma, depletion of CD25(+)Tregs results in tumour regression in Balb/c mice, but the mechanisms underlying this process are not f...

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Detalles Bibliográficos
Autores principales: Goudin, Nicolas, Chappert, Pascal, Mégret, Jérome, Gross, David-Alexandre, Rocha, Benedita, Azogui, Orly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920347/
https://www.ncbi.nlm.nih.gov/pubmed/27341421
http://dx.doi.org/10.1371/journal.pone.0157822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920347/
https://www.ncbi.nlm.nih.gov/pubmed/27341421
http://dx.doi.org/10.1371/journal.pone.0157822

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