GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism

GPR142, a putative amino acid receptor, is expressed in pancreatic islets and the gastrointestinal tract, but the ligand affinity and physiological role of this receptor remain obscure. In this study, we show that in addition to L-Tryptophan, GPR142 signaling is also activated by L-Phenylalanine but...

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Detalles Bibliográficos
Autores principales: Lin, Hua V., Efanov, Alexander M., Fang, Xiankang, Beavers, Lisa S., Wang, Xuesong, Wang, Jingru, Gonzalez Valcarcel, Isabel C., Ma, Tianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920590/
https://www.ncbi.nlm.nih.gov/pubmed/27322810
http://dx.doi.org/10.1371/journal.pone.0157298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920590/
https://www.ncbi.nlm.nih.gov/pubmed/27322810
http://dx.doi.org/10.1371/journal.pone.0157298

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