T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super el...

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Detalles Bibliográficos
Autores principales: Hertweck, Arnulf, Evans, Catherine M., Eskandarpour, Malihe, Lau, Jonathan C.H., Oleinika, Kristine, Jackson, Ian, Kelly, Audrey, Ambrose, John, Adamson, Peter, Cousins, David J., Lavender, Paul, Calder, Virginia L., Lord, Graham M., Jenner, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920892/
https://www.ncbi.nlm.nih.gov/pubmed/27292648
http://dx.doi.org/10.1016/j.celrep.2016.05.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920892/
https://www.ncbi.nlm.nih.gov/pubmed/27292648
http://dx.doi.org/10.1016/j.celrep.2016.05.054

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