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T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super el...
Autores principales: | Hertweck, Arnulf, Evans, Catherine M., Eskandarpour, Malihe, Lau, Jonathan C.H., Oleinika, Kristine, Jackson, Ian, Kelly, Audrey, Ambrose, John, Adamson, Peter, Cousins, David J., Lavender, Paul, Calder, Virginia L., Lord, Graham M., Jenner, Richard G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920892/ https://www.ncbi.nlm.nih.gov/pubmed/27292648 http://dx.doi.org/10.1016/j.celrep.2016.05.054 |
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