Non-Markovian effects on protein sequence evolution due to site dependent substitution rates

BACKGROUND: Many models of protein sequence evolution, in particular those based on Point Accepted Mutation (PAM) matrices, assume that its dynamics is Markovian. Nevertheless, it has been observed that evolution seems to proceed differently at different time scales, questioning this assumption. In...

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Detalles Bibliográficos
Autores principales: Rizzato, Francesca, Rodriguez, Alex, Laio, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921000/
https://www.ncbi.nlm.nih.gov/pubmed/27342318
http://dx.doi.org/10.1186/s12859-016-1135-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921000/
https://www.ncbi.nlm.nih.gov/pubmed/27342318
http://dx.doi.org/10.1186/s12859-016-1135-1

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