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Non-Markovian effects on protein sequence evolution due to site dependent substitution rates
BACKGROUND: Many models of protein sequence evolution, in particular those based on Point Accepted Mutation (PAM) matrices, assume that its dynamics is Markovian. Nevertheless, it has been observed that evolution seems to proceed differently at different time scales, questioning this assumption. In...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921000/ https://www.ncbi.nlm.nih.gov/pubmed/27342318 http://dx.doi.org/10.1186/s12859-016-1135-1 |