Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

PURPOSE: Xenograft studies are commonly used to assess the efficacy of new compounds and characterise their dose–response relationship. Analysis often involves comparing the final tumour sizes across dose groups. This can cause bias, as often in xenograft studies a tumour burden limit (TBL) is impos...

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Detalles Bibliográficos
Autores principales: Martin, Emma C., Aarons, Leon, Yates, James W. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921113/
https://www.ncbi.nlm.nih.gov/pubmed/27220867
http://dx.doi.org/10.1007/s00280-016-3059-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921113/
https://www.ncbi.nlm.nih.gov/pubmed/27220867
http://dx.doi.org/10.1007/s00280-016-3059-x

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