Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (V(HHs)) to the N-terminus of a human collagen XVIII trimerization domain (TIE(XVIII)) we...

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Detalles Bibliográficos
Autores principales: Alvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Compte, Marta, Cuesta, Angel M., Blanco-Toribio, Ana, Harwood, Seandean Lykke, Villate, Maider, Merino, Nekane, Bonet, Jaume, Navarro, Rocio, Muñoz-Briones, Clara, Sørensen, Karen Marie Juul, Mølgaard, Kasper, Oliva, Baldo, Sanz, Laura, Blanco, Francisco J., Alvarez-Vallina, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921811/
https://www.ncbi.nlm.nih.gov/pubmed/27345490
http://dx.doi.org/10.1038/srep28643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921811/
https://www.ncbi.nlm.nih.gov/pubmed/27345490
http://dx.doi.org/10.1038/srep28643

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