Cargando…

3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway

The epithelial to mesenchymal transition (EMT) is a critical developmental program in cancer stem cell (CSC) maintenance and in cancer metastasis. Here, our study found that 3,6-DHF could effectively inhibit EMT in BC cells in vitro and in vivo. 3,6-DHF effectively inhibits the formation and prolife...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Junli, Chang, Hui, Peng, Xiaoli, Gu, Yeyun, Yi, Long, Zhang, Qianyong, Zhu, Jundong, Mi, Mantian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921838/ https://www.ncbi.nlm.nih.gov/pubmed/27345219 http://dx.doi.org/10.1038/srep28858

Ejemplares similares

3,6-Dihydroxyflavone regulates microRNA-34a through DNA methylation
por: Peng, Xiaoli, et al.
Publicado: (2017)

MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis
por: Hui, Chang, et al.
Publicado: (2012)

Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of Epidemiologic Studies
por: Hui, Chang, et al.
Publicado: (2013)

Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization
por: Zhou, Xi, et al.
Publicado: (2022)

Long-term high loading intensity of aerobic exercise improves skeletal muscle performance via the gut microbiota-testosterone axis
por: Zhang, Lidong, et al.
Publicado: (2022)

Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway
por: Zang, Ming-de, et al.
Publicado: (2017)

Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway
por: Fu, Yujie, et al.
Publicado: (2014)

Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer
por: Pal, Deeksha, et al.
Publicado: (2018)

Ampelopsin Improves Insulin Resistance by Activating PPARγ and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway
por: Zhou, Yong, et al.
Publicado: (2016)

Pterostilbene attenuates intestinal epithelial barrier loss induced by high loading intensity of exercise
por: Zhang, Lidong, et al.
Publicado: (2022)

Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer
por: Liao, Yun, et al.
Publicado: (2014)

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
por: Espinoza, Ingrid, et al.
Publicado: (2013)

Cytotoxic Activity of 3,6-Dihydroxyflavone in Human Cervical Cancer Cells and Its Therapeutic Effect on c-Jun N-Terminal Kinase Inhibition
por: Lee, Eunjung, et al.
Publicado: (2014)

CD36 promotes the epithelial–mesenchymal transition and metastasis in cervical cancer by interacting with TGF-β
por: Deng, Min, et al.
Publicado: (2019)

NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma
por: Zou, You, et al.
Publicado: (2019)

Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
por: Kim, Rae-Kwon, et al.
Publicado: (2016)

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
por: Bocci, Federico, et al.
Publicado: (2017)

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer
por: Kar, Rohan, et al.
Publicado: (2019)

DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma
por: Zhou, Qing, et al.
Publicado: (2019)

Paraquat poisoning induced pulmonary epithelial mesenchymal transition through Notch1 pathway
por: Li, Tiegang, et al.
Publicado: (2017)

Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner
por: Shao, Shan, et al.
Publicado: (2015)

The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells
por: Liu, Xianpeng, et al.
Publicado: (2017)

Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia
por: Liu, Lei, et al.
Publicado: (2017)

Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells
por: Zhang, Ting, et al.
Publicado: (2016)

Estrogen Receptor and PI3K/Akt Signaling Pathway Involvement in S-(-)Equol-Induced Activation of Nrf2/ARE in Endothelial Cells
por: Zhang, Ting, et al.
Publicado: (2013)

AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells
por: Yoshinaga, Tomoyo, et al.
Publicado: (2016)

Emodin inhibiting neutrophil elastase‐induced epithelial‐mesenchymal transition through Notch1 signalling in alveolar epithelial cells
por: Zhou, Linshui, et al.
Publicado: (2020)

Notch1 Affects Chemo-resistance Through Regulating Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian cancer cells
por: Qian, Xue-qian, et al.
Publicado: (2020)

The essential role of YAP in ERα36-mediated proliferation and the epithelial-mesenchymal transition in MCF-7 breast cancer cells
por: Park, Miso, et al.
Publicado: (2022)

Dihydromyricetin Enhances Exercise-Induced GLP-1 Elevation through Stimulating cAMP and Inhibiting DPP-4
por: Wu, Luting, et al.
Publicado: (2022)

Dihydromyricetin Protects Intestinal Barrier Integrity by Promoting IL-22 Expression in ILC3s through the AMPK/SIRT3/STAT3 Signaling Pathway
por: Zhou, Jie, et al.
Publicado: (2023)

RAD18 promotes colorectal cancer metastasis by activating the epithelial-mesenchymal transition pathway
por: Li, Peng, et al.
Publicado: (2020)

Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8
por: Ji, Shufang, et al.
Publicado: (2016)

MiR-520d-3p suppresses the proliferation and epithelial-mesenchymal transition of cervical cancer cells by targeting ZFP36L2
por: Zhang, Yuan, et al.
Publicado: (2023)

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut
por: Chanrion, Maia, et al.
Publicado: (2014)

Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity
por: Noh, Hae Sook, et al.
Publicado: (2015)

Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis
por: Qi, Shasha, et al.
Publicado: (2015)

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
por: Zhang, Jianchao, et al.
Publicado: (2016)

Notch signaling is important for epithelial-mesenchymal transition induced by low concentrations of doxorubicin in osteosarcoma cell lines
por: Yang, Jian, et al.
Publicado: (2017)

Tspan5 promotes epithelial–mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling
por: Xie, Qian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v9qhdbchm7ev6djccdsn7q9c4e