Cargando…

Curcumin protects mice from Staphylococcus aureus pneumonia by interfering with the self-assembly process of α-hemolysin

α-hemolysin (Hla) is a self-assembling extracellular protein secreted as a soluble monomer by most Staphylococcus aureus strains and is an essential virulence factor for the pathogenesis of various S. aureus infections. Here, we show that curcumin (CUR), a natural compound with weak anti-S. aureus a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jianfeng, Zhou, Xuan, Li, Wenhua, Deng, Xuming, Deng, Yanhong, Niu, Xiaodi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921848/ https://www.ncbi.nlm.nih.gov/pubmed/27345357 http://dx.doi.org/10.1038/srep28254

Ejemplares similares

Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin
por: Zhang, Bing, et al.
Publicado: (2017)

A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection
por: Wang, Tingting, et al.
Publicado: (2020)

Oroxylin A Inhibits Hemolysis via Hindering the Self-Assembly of α-Hemolysin Heptameric Transmembrane Pore
por: Dong, Jing, et al.
Publicado: (2013)

Two residues in Staphylococcus aureus α-hemolysin related to hemolysis and self-assembly
por: Du, Yufeng, et al.
Publicado: (2018)

Subinhibitory Concentrations of Thymol Reduce Enterotoxins A and B and α-Hemolysin Production in Staphylococcus aureus Isolates
por: Qiu, Jiazhang, et al.
Publicado: (2010)

Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for Staphylococcus aureus
por: Wang, Jianfeng, et al.
Publicado: (2018)

Capsaicin Protects Mice from Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonia
por: Qiu, Jiazhang, et al.
Publicado: (2012)

Inhibitory Effect of Andrographis paniculata Lactone on Staphylococcus aureus α-Hemolysin
por: Wang, Xin, et al.
Publicado: (2022)

Application of Oleanolic Acid and Its Analogues in Combating Pathogenic Bacteria In Vitro/Vivo by a Two-Pronged Strategy of β-Lactamases and Hemolysins
por: Zhou, Yonglin, et al.
Publicado: (2020)

Staphylococcus aureus Induces Eosinophil Cell Death Mediated by α-hemolysin
por: Prince, Lynne R., et al.
Publicado: (2012)

Bavachin Suppresses Alpha-Hemolysin Expression and Protects Mice from Pneumonia Infection by Staphylococcus aureus
por: Tao, Ye, et al.
Publicado: (2022)

Quercetin protects rats from catheter‐related Staphylococcus aureus infections by inhibiting coagulase activity
por: Wang, Lin, et al.
Publicado: (2019)

Aloe-emodin Attenuates Staphylococcus aureus Pathogenicity by Interfering With the Oligomerization of α-Toxin
por: Jiang, Lanxiang, et al.
Publicado: (2019)

Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3,3’-digallate
por: Goc, Anna, et al.
Publicado: (2023)

Novel Structurally Designed Vaccine for S. aureus α-Hemolysin: Protection against Bacteremia and Pneumonia
por: Adhikari, Rajan P., et al.
Publicado: (2012)

Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin
por: Fiaschi, Luigi, et al.
Publicado: (2016)

Fosfomycin Protects Mice From Staphylococcus aureus Pneumonia Caused by α-Hemolysin in Extracellular Vesicles by Inhibiting MAPK-Regulated NLRP3 Inflammasomes
por: An, Yanan, et al.
Publicado: (2019)

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells
por: Craven, Robin R., et al.
Publicado: (2009)

An Important Role of α-Hemolysin in Extracellular Vesicles on the Development of Atopic Dermatitis Induced by Staphylococcus aureus
por: Hong, Sung-Wook, et al.
Publicado: (2014)

Tailored Phenyl Esters Inhibit ClpXP and Attenuate Staphylococcus aureus α‐Hemolysin Secretion
por: Schwarz, Markus, et al.
Publicado: (2022)

The natural product, echinatin, protects mice from methicillin-resistant Staphylococcus aureus pneumonia by inhibition of alpha-hemolysin expression
por: Zhang, Wei, et al.
Publicado: (2023)

Molecular Modeling Reveals the Novel Inhibition Mechanism and Binding Mode of Three Natural Compounds to Staphylococcal α-Hemolysin
por: Qiu, Jiazhang, et al.
Publicado: (2013)

Inhibition of Staphylococcus aureus α-Hemolysin Production Using Nanocurcumin Capped Au@ZnO Nanocomposite
por: Jabir, Majid S., et al.
Publicado: (2022)

Loaded delta-hemolysin shapes the properties of Staphylococcus aureus membrane vesicles
por: Chen, Juan, et al.
Publicado: (2023)

Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence
por: Pivard, Mariane, et al.
Publicado: (2023)

Pathogenic Effect of Prevotella intermedia on a Mouse Pneumonia Model Due to Methicillin-Resistant Staphylococcus aureus With Up-Regulated α-Hemolysin Expression
por: Yamashita, Yu, et al.
Publicado: (2020)

Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300)
por: Ping, Ouyang, et al.
Publicado: (2018)

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution
por: Jordan, Paul M., et al.
Publicado: (2020)

Epigallocatechin gallate inhibits Streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase A
por: Song, Meng, et al.
Publicado: (2017)

Hyperexpression of α-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus
por: Chua, Kyra YL, et al.
Publicado: (2014)

Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity
por: Virreira Winter, Sebastian, et al.
Publicado: (2016)

Genotypic Diversity of Staphylococcus aureus α-Hemolysin Gene (hla) and Its Association with Clonal Background: Implications for Vaccine Development
por: Xiao, Meng, et al.
Publicado: (2016)

Inhibition of interaction between Staphylococcus aureus α-hemolysin and erythrocytes membrane by hydrolysable tannins: structure-related activity study
por: Olchowik-Grabarek, Ewa, et al.
Publicado: (2020)

Redirecting Pore Assembly of Staphylococcal α-Hemolysin by Protein Engineering
por: Koo, Sunwoo, et al.
Publicado: (2019)

Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase
por: Burnside, Kellie, et al.
Publicado: (2010)

The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition
por: Wang, Lin, et al.
Publicado: (2015)

Baicalin Weakens Staphylococcus aureus Pathogenicity by Targeting Sortase B
por: Wang, Guizhen, et al.
Publicado: (2018)

Virulence gene profiles: alpha-hemolysin and clonal diversity in Staphylococcus aureus isolates from bovine clinical mastitis in China
por: Zhang, Limei, et al.
Publicado: (2018)

Inhibitory effect of probiotic yeast Saccharomyces cerevisiae on biofilm formation and expression of α-hemolysin and enterotoxin A genes of Staphylococcus aureus
por: Saidi, Navid, et al.
Publicado: (2019)

Inhibitory effect of theaflavin-3,3′-digallate can involve its binding to the “stem” domain of α-hemolysin of Staphylococcus aureus
por: Goc, Anna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3j8mmfd1spivft4c5n38sdiglc