Cargando…

DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma

Studies indicate that the presence of cancer stem cells (CSCs) is responsible for poor prognosis of hepatocellular carcinoma (HCC) patients. In this study, the functional role of DDX3 in regulation of hepatic CSCs was investigated. Our results demonstrated that reduced DDX3 expression was not only i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hao-Kang, Mai, Ru-Tsun, Huang, Hsien-Da, Chou, Chih-Hung, Chang, Yi-An, Chang, Yao-Wen, You, Li-Ru, Chen, Chun-Ming, Lee, Yan-Hwa Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921922/ https://www.ncbi.nlm.nih.gov/pubmed/27344963 http://dx.doi.org/10.1038/srep28637

Ejemplares similares

DDX3 depletion represses translation of mRNAs with complex 5′ UTRs
por: Calviello, Lorenzo, et al.
Publicado: (2021)

How do miRNAs mediate translational repression?
por: Gu, Shuo, et al.
Publicado: (2010)

DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression
por: Lin, Tsung-Chieh
Publicado: (2020)

The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs
por: Nicklas, Sarah, et al.
Publicado: (2015)

DDX3X promotes the biogenesis of a subset of miRNAs and the potential roles they played in cancer development
por: Zhao, Luqing, et al.
Publicado: (2016)

The role of epigenetics and miRNAs in neuroblastoma development
por: Rupani, KV, et al.
Publicado: (2012)

DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression
por: Chen, Wei-Ju, et al.
Publicado: (2017)

Role of SNPs in the Biogenesis of Mature miRNAs
por: Wang, Ying, et al.
Publicado: (2021)

DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma
por: Wu, Qingqing, et al.
Publicado: (2021)

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression
por: Chu, Rui, et al.
Publicado: (2014)

The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing
por: Kim, Jessica, et al.
Publicado: (2022)

MicroRNAs serve as prediction and treatment-response biomarkers of attention-deficit/hyperactivity disorder and promote the differentiation of neuronal cells by repressing the apoptosis pathway
por: Wang, Liang-Jen, et al.
Publicado: (2022)

RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation
por: Li, Zonghong, et al.
Publicado: (2018)

The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness
por: Wu, Kou-Juey
Publicado: (2020)

The DDX6–4E-T interaction mediates translational repression and P-body assembly
por: Kamenska, Anastasiia, et al.
Publicado: (2016)

miRNA arm selection and isomiR distribution in gastric cancer
por: Li, Sung-Chou, et al.
Publicado: (2012)

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation
por: Aibara, Daisuke, et al.
Publicado: (2022)

Differential expression of miRNAs in enterovirus 71-infected cells
por: Xun, Meng, et al.
Publicado: (2015)

Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals
por: Bosutti, Alessandra, et al.
Publicado: (2016)

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association
por: Zhang, Wangmeng, et al.
Publicado: (2022)

A Comprehensive Review of miRNAs and Their Epigenetic Effects in Glioblastoma
por: Hasan, Hera, et al.
Publicado: (2023)

Epigenetic hypomethylation and upregulation of matrix metalloproteinase 9 in Kawasaki disease
por: Kuo, Ho-Chang, et al.
Publicado: (2017)

Exosomal miRNAs in hepatocellular carcinoma development and clinical responses
por: Li, Shuangshuang, et al.
Publicado: (2018)

miRNAs trigger widespread epigenetically-activated siRNAs from transposons in Arabidopsis
por: Creasey, K.M., et al.
Publicado: (2014)

An antisense intragenic lncRNA SEAIRa mediates transcriptional and epigenetic repression of SERRATE in Arabidopsis
por: Chen, Wei, et al.
Publicado: (2023)

Little things with significant impact: miRNAs in hepatocellular carcinoma
por: Li, Jiehan, et al.
Publicado: (2023)

The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma
por: Bai, Xue, et al.
Publicado: (2019)

Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription
por: Hulf, Toby, et al.
Publicado: (2011)

Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs
por: Lai, Xin, et al.
Publicado: (2012)

Rationally designed siRNAs without miRNA-like off-target repression
por: Seok, Heeyoung, et al.
Publicado: (2016)

Repression of Irs2 by let‐7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium
por: Fernández, Virginia, et al.
Publicado: (2020)

PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
por: Shivram, Haridha, et al.
Publicado: (2019)

Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma
por: Wang, Li-Ting, et al.
Publicado: (2016)

Epigenetic and post-transcriptional repression support metabolic suppression in chronically hypoxic goldfish
por: Farhat, Elie, et al.
Publicado: (2022)

C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells
por: Li, Shu-Guang, et al.
Publicado: (2018)

DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
por: Xu, Kun, et al.
Publicado: (2022)

Dystrophin Orchestrates the Epigenetic Profile of Muscle Cells Via miRNAs
por: Marrone, April K., et al.
Publicado: (2011)

RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action
por: Masliah-Planchon, Julien, et al.
Publicado: (2015)

DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
por: Shi, Min, et al.
Publicado: (2017)

Associations of DDX60L With the Clinical Features and Prognosis of Hepatocellular Carcinoma
por: Ye, Ziqi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3cntm9omj1ei1adr99sp4gioqv