X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism

[Image: see text] Ruthenium(III) complexes are promising candidates for anticancer drugs, especially the clinically studied indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and its analogue sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (NKP-1339). Several studies have...

Descripción completa

Detalles Bibliográficos
Autores principales: Bijelic, Aleksandar, Theiner, Sarah, Keppler, Bernhard K., Rompel, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921950/
https://www.ncbi.nlm.nih.gov/pubmed/27196130
http://dx.doi.org/10.1021/acs.jmedchem.6b00600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921950/
https://www.ncbi.nlm.nih.gov/pubmed/27196130
http://dx.doi.org/10.1021/acs.jmedchem.6b00600

Ejemplares similares