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Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies()

Human serum IgG contains multiple glycoforms which exhibit a range of binding properties to effector molecules such as cellular Fc receptors. Emerging knowledge of how the Fc glycans contribute to the antibody structure and effector functions has opened new avenues for the exploitation of defined an...

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Detalles Bibliográficos
Autores principales: Le, Ngoc Phuong Lan, Bowden, Thomas A., Struwe, Weston B., Crispin, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922387/
https://www.ncbi.nlm.nih.gov/pubmed/27105835
http://dx.doi.org/10.1016/j.bbagen.2016.04.016