Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology

Acetylpuerarin (AP), an acetylated derivative of puerarin, shows brain-protective effects in animals. However, AP has low oral bioavailability because of its poor water solubility. The objective of this study was to design and develop poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) to enhance...

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Detalles Bibliográficos
Autores principales: Sun, Deqing, Xue, Aiying, Zhang, Bin, Xue, Xia, Zhang, Jie, Liu, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922808/
https://www.ncbi.nlm.nih.gov/pubmed/27382256
http://dx.doi.org/10.2147/DDDT.S108185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922808/
https://www.ncbi.nlm.nih.gov/pubmed/27382256
http://dx.doi.org/10.2147/DDDT.S108185

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