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Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology

Acetylpuerarin (AP), an acetylated derivative of puerarin, shows brain-protective effects in animals. However, AP has low oral bioavailability because of its poor water solubility. The objective of this study was to design and develop poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) to enhance...

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Detalles Bibliográficos
Autores principales:	Sun, Deqing, Xue, Aiying, Zhang, Bin, Xue, Xia, Zhang, Jie, Liu, Wenjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922808/ https://www.ncbi.nlm.nih.gov/pubmed/27382256 http://dx.doi.org/10.2147/DDDT.S108185

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