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Atypical calcium regulation of the PKD2-L1 polycystin ion channel

Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function. We report that the human PKD2-L1 selectivity...

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Detalles Bibliográficos
Autores principales: DeCaen, Paul G, Liu, Xiaowen, Abiria, Sunday, Clapham, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922860/
https://www.ncbi.nlm.nih.gov/pubmed/27348301
http://dx.doi.org/10.7554/eLife.13413