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The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice

Both TDP-43 pathology and failure of RNA editing of AMPA receptor subunit GluA2, are etiology-linked molecular abnormalities that concomitantly occur in the motor neurons of the majority of patients with amyotrophic lateral sclerosis (ALS). AR2 mice, in which an RNA editing enzyme adenosine deaminas...

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Detalles Bibliográficos
Autores principales: Akamatsu, Megumi, Yamashita, Takenari, Hirose, Naoki, Teramoto, Sayaka, Kwak, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923865/
https://www.ncbi.nlm.nih.gov/pubmed/27350567
http://dx.doi.org/10.1038/srep28649