The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice

Both TDP-43 pathology and failure of RNA editing of AMPA receptor subunit GluA2, are etiology-linked molecular abnormalities that concomitantly occur in the motor neurons of the majority of patients with amyotrophic lateral sclerosis (ALS). AR2 mice, in which an RNA editing enzyme adenosine deaminas...

Descripción completa

Detalles Bibliográficos
Autores principales: Akamatsu, Megumi, Yamashita, Takenari, Hirose, Naoki, Teramoto, Sayaka, Kwak, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923865/
https://www.ncbi.nlm.nih.gov/pubmed/27350567
http://dx.doi.org/10.1038/srep28649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923865/
https://www.ncbi.nlm.nih.gov/pubmed/27350567
http://dx.doi.org/10.1038/srep28649

Ejemplares similares