Functional map of arrestin binding to phosphorylated opsin, with and without agonist

Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of signalling. Here we investigated the interactions of arrestin-1 with two functionally distinct forms of the dim-light photoreceptor rhodopsin. Using unbiased scanning mutagenesis we probed the individual contribution o...

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Detalles Bibliográficos
Autores principales: Peterhans, Christian, Lally, Ciara C. M., Ostermaier, Martin K., Sommer, Martha E., Standfuss, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923902/
https://www.ncbi.nlm.nih.gov/pubmed/27350090
http://dx.doi.org/10.1038/srep28686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923902/
https://www.ncbi.nlm.nih.gov/pubmed/27350090
http://dx.doi.org/10.1038/srep28686

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