Stereoselective Access to Tubuphenylalanine and Tubuvaline: Improved Mn-Mediated Radical Additions and Assembly of A Tubulysin Tetrapeptide Analog

Synthesis of tubuphenylalanine and tubuvaline, α-substituted γ-amino acid building blocks for tubulysin family of antimitotic compounds, has been improved using a radical addition reaction in the presence of unprotected hydroxyl functionality. The key carbon–carbon bond construction entails stereose...

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Detalles Bibliográficos
Autores principales: Friestad, Gregory K., Banerjee, Koushik, Marié, Jean-Charles, Mali, Umesh, Yao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924578/
https://www.ncbi.nlm.nih.gov/pubmed/26883395
http://dx.doi.org/10.1038/ja.2016.7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924578/
https://www.ncbi.nlm.nih.gov/pubmed/26883395
http://dx.doi.org/10.1038/ja.2016.7

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