Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis

Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallm...

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Detalles Bibliográficos
Autores principales: O'Hagan-Wong, Kelsey, Nadeau, Stéphanie, Carrier-Leclerc, Audrey, Apablaza, Felipe, Hamdy, Reggie, Shum-Tim, Dominique, Rodier, Francis, Colmegna, Inés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924641/
https://www.ncbi.nlm.nih.gov/pubmed/26934440
http://dx.doi.org/10.18632/oncotarget.7690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924641/
https://www.ncbi.nlm.nih.gov/pubmed/26934440
http://dx.doi.org/10.18632/oncotarget.7690

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