Cargando…

Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis

Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallm...

Descripción completa

Detalles Bibliográficos
Autores principales:	O'Hagan-Wong, Kelsey, Nadeau, Stéphanie, Carrier-Leclerc, Audrey, Apablaza, Felipe, Hamdy, Reggie, Shum-Tim, Dominique, Rodier, Francis, Colmegna, Inés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924641/ https://www.ncbi.nlm.nih.gov/pubmed/26934440 http://dx.doi.org/10.18632/oncotarget.7690

Ejemplares similares

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21
por: Lee, Hyemin, et al.
Publicado: (2016)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
por: Özcan, Servet, et al.
Publicado: (2015)

Rapamycin preserves gut homeostasis during Drosophila aging
por: Fan, Xiaolan, et al.
Publicado: (2015)

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice
por: Selman, Colin, et al.
Publicado: (2016)

Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression
por: Peng, Yanfei, et al.
Publicado: (2017)

miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis
por: Almeida, Maria Ines, et al.
Publicado: (2015)

Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells
por: Capasso, Stefania, et al.
Publicado: (2015)

Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice
por: Zou, Donghua, et al.
Publicado: (2016)

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts
por: Gabriel, Diana, et al.
Publicado: (2017)

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways
por: Fu, Cong, et al.
Publicado: (2015)

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism
por: van der Eerden, Bram C.J., et al.
Publicado: (2016)

The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons
por: Vezzali, Riccardo, et al.
Publicado: (2016)

Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response
por: Aquilano, Katia, et al.
Publicado: (2016)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice
por: Mitchell, Sharon E., et al.
Publicado: (2015)

Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner
por: Thériault, Peter, et al.
Publicado: (2016)

A Proinflammatory Secretome Mediates the Impaired Immunopotency of Human Mesenchymal Stromal Cells in Elderly Patients with Atherosclerosis
por: Kizilay Mancini, Özge, et al.
Publicado: (2017)

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes
por: Gao, Junjie, et al.
Publicado: (2016)

Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice
por: Yang, Xue, et al.
Publicado: (2015)

Human prion protein-induced autophagy flux governs neuron cell damage in primary neuron cells
por: Moon, Ji-Hong, et al.
Publicado: (2016)

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
por: Prattichizzo, Francesco, et al.
Publicado: (2016)

Zinc finger factor 521 enhances adipogenic differentiation of mouse multipotent cells and human bone marrow mesenchymal stem cells
por: Tseng, Kuo-Yun, et al.
Publicado: (2015)

Age-related changes in the transcriptome of antibody-secreting cells
por: Kannan, Senthil, et al.
Publicado: (2016)

Vaccine efficacy and T helper cell differentiation change with aging
por: Lefebvre, Julie S., et al.
Publicado: (2016)

CLEC4C p.K210del variant causes impaired cell surface transport in plasmacytoid dendritic cells of amyotrophic lateral sclerosis
por: Lim, Su Min, et al.
Publicado: (2016)

Are TKIs favourable for the elderly with non-small-cell lung cancer?
por: Rossi, Sabrina, et al.
Publicado: (2016)

VPO1 mediates oxidation of LDL and formation of foam cells
por: Yang, Youfeng, et al.
Publicado: (2016)

Age-related alterations in blood and colonic dendritic cell properties
por: Vora, Rakesh, et al.
Publicado: (2016)

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence
por: Niu, Ping, et al.
Publicado: (2015)

Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells
por: Makarev, Eugene, et al.
Publicado: (2015)

Systemic analysis of gene expression profiles in porcine granulosa cells during aging
por: Hui, Li, et al.
Publicado: (2017)

Interferon-gamma deficiency protects against aging-related goblet cell loss
por: Volpe, Eugene A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4vgpk38lbthihujadov45oaptn