Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT(1A) receptor mediated Akt/GSK-3β pathway

Tau hyperphosphorylation is an important pathological feature of Alzheimer's disease (AD). To investigate whether escitalopram could inhibit amyloid-β (Aβ)-induced tau hyperphosphorylation and the underlying mechanisms, we treated the rat primary hippocampal neurons with Aβ(1-42) and examined t...

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Detalles Bibliográficos
Autores principales: Wang, Yan-Juan, Ren, Qing-Guo, Gong, Wei-Gang, Wu, Di, Tang, Xiang, Li, Xiao-Li, Wu, Fang-Fang, Bai, Feng, Xu, Lin, Zhang, Zhi-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924645/
https://www.ncbi.nlm.nih.gov/pubmed/26950279
http://dx.doi.org/10.18632/oncotarget.7798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924645/
https://www.ncbi.nlm.nih.gov/pubmed/26950279
http://dx.doi.org/10.18632/oncotarget.7798

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