Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy

GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which encodes a key enzyme in sialic acid biosynthe...

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Detalles Bibliográficos
Autores principales: Bosch-Morató, Mònica, Iriondo, Cinta, Guivernau, Biuse, Valls-Comamala, Victòria, Vidal, Noemí, Olivé, Montse, Querfurth, Henry, Muñoz, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924647/
https://www.ncbi.nlm.nih.gov/pubmed/26968811
http://dx.doi.org/10.18632/oncotarget.7997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924647/
https://www.ncbi.nlm.nih.gov/pubmed/26968811
http://dx.doi.org/10.18632/oncotarget.7997

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