SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells

Most chemotherapeutic agents for leukemia are DNA damaging agents. However, DNA lesions can be repaired by activities of DNA repair systems. Increasing evidence have shown that enhanced DNA damage repair capacity contributes to chemotherapy resistance in leukemia cells. Thus, targeting DNA repair me...

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Detalles Bibliográficos
Autores principales: Zhang, Wenjun, Wu, Haixia, Yang, Meng, Ye, Shiguang, Li, Liang, Zhang, Hong, Hu, Jiong, Wang, Xuguang, Xu, Jun, Liang, Aibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924659/
https://www.ncbi.nlm.nih.gov/pubmed/26646449
http://dx.doi.org/10.18632/oncotarget.6455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924659/
https://www.ncbi.nlm.nih.gov/pubmed/26646449
http://dx.doi.org/10.18632/oncotarget.6455

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