Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes

Hypoxia-inducible factor-1 alpha (HIF-1α) is over-expressed in many cancers including pancreatic ductal adenocarcinoma (PDAC) and correlated with poor prognosis. We aim to determine the effect of germline genetic variants on the regulation of the homeostasis of the miRNA-gene regulatory loop in HIF1...

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Detalles Bibliográficos
Autores principales: Wang, Xiuchao, Ren, He, Zhao, Tiansuo, Ma, Weidong, Dong, Jie, Zhang, Shengjie, Xin, Wen, Yang, Shengyu, Jia, Li, Hao, Jihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924673/
https://www.ncbi.nlm.nih.gov/pubmed/26872370
http://dx.doi.org/10.18632/oncotarget.7263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924673/
https://www.ncbi.nlm.nih.gov/pubmed/26872370
http://dx.doi.org/10.18632/oncotarget.7263

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