Cargando…

Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes

Hypoxia-inducible factor-1 alpha (HIF-1α) is over-expressed in many cancers including pancreatic ductal adenocarcinoma (PDAC) and correlated with poor prognosis. We aim to determine the effect of germline genetic variants on the regulation of the homeostasis of the miRNA-gene regulatory loop in HIF1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiuchao, Ren, He, Zhao, Tiansuo, Ma, Weidong, Dong, Jie, Zhang, Shengjie, Xin, Wen, Yang, Shengyu, Jia, Li, Hao, Jihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924673/ https://www.ncbi.nlm.nih.gov/pubmed/26872370 http://dx.doi.org/10.18632/oncotarget.7263

Ejemplares similares

SCF, Regulated by HIF-1α, Promotes Pancreatic Ductal Adenocarcinoma Cell Progression
por: Gao, Chuntao, et al.
Publicado: (2015)

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
por: Zhao, Tiansuo, et al.
Publicado: (2014)

Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
por: Zhao, Tiansuo, et al.
Publicado: (2019)

Serum insulin‐like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma‐associated malnutrition and muscle wasting
por: Dong, Jie, et al.
Publicado: (2021)

IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer
por: Zhao, Tiansuo, et al.
Publicado: (2020)

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
por: Huang, Chongbiao, et al.
Publicado: (2017)

Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma
por: Liu, Jing, et al.
Publicado: (2019)

MicroRNA-608 promotes apoptosis via BRD4 downregulation in pancreatic ductal adenocarcinoma
por: Li, Maoyuan, et al.
Publicado: (2020)

Hypoxia-Inducible Factor-1α Regulates Chemotactic Migration of Pancreatic Ductal Adenocarcinoma Cells through Directly Transactivating the CX3CR1 Gene
por: Zhao, Tiansuo, et al.
Publicado: (2012)

Survival outcomes of neoadjuvant therapy followed by radical resection versus upfront surgery for stage I–III pancreatic ductal adenocarcinoma: a retrospective cohort study
por: Zou, Yiping, et al.
Publicado: (2023)

CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC
por: Zhang, Huan, et al.
Publicado: (2014)

Crosstalk Between Peripheral Innervation and Pancreatic Ductal Adenocarcinoma
por: Ni, Bo, et al.
Publicado: (2023)

Proteasome inhibitor MG132 suppresses pancreatic ductal adenocarcinoma-cell migration by increasing ESE3 expression
por: Jin, Fanjie, et al.
Publicado: (2020)

Effect of Perioperative CEA and CA24-2 on Prognosis of Early Resectable Pancreatic Ductal Adenocarcinoma
por: Li, Xiaojie, et al.
Publicado: (2020)

Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma
por: Qian, Yunzhen, et al.
Publicado: (2022)

PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC
por: Wang, Xiuchao, et al.
Publicado: (2020)

Specific Subtypes of Carcinoma-Associated Fibroblasts Are Correlated with Worse Survival in Resectable Pancreatic Ductal Adenocarcinoma
por: Knipper, Karl, et al.
Publicado: (2023)

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma
por: Fu, Danqi, et al.
Publicado: (2023)

Systemic Inflammatory Response and Elevated Tumour Markers Predict Worse Survival in Resectable Pancreatic Ductal Adenocarcinoma
por: Salmiheimo, Aino, et al.
Publicado: (2016)

Preoperative ultrasound combined with routine blood tests in predicting the malignant risk of pancreatic cystic neoplasms
por: Wang, Xiuchao, et al.
Publicado: (2022)

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma
por: Leppänen, Joni, et al.
Publicado: (2018)

The State of the Art on Blood MicroRNAs in Pancreatic Ductal Adenocarcinoma
por: Gao, Zhuqing, et al.
Publicado: (2019)

ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis
por: Zhao, Tiansuo, et al.
Publicado: (2022)

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer
por: Bhaumik, Panchalee, et al.
Publicado: (2014)

Predictive value of CONUT score combined with serum CA199 levels in postoperative survival of patients with pancreatic ductal adenocarcinoma: a retrospective study
por: Wang, Ankang, et al.
Publicado: (2020)

CA19.9 Serum Level Predicts Lymph-Nodes Status in Resectable Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Analysis
por: Coppola, Alessandro, et al.
Publicado: (2021)

BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis
por: Huang, Chongbiao, et al.
Publicado: (2023)

Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma
por: Mortoglou, Maria, et al.
Publicado: (2021)

microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells
por: Mortoglou, Maria, et al.
Publicado: (2022)

Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs
por: Mortoglou, Maria, et al.
Publicado: (2022)

A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma
por: Liang, Yuexiang, et al.
Publicado: (2023)

Hypoxia Inducible Factor 1 (HIF-1) Recruits Macrophage to Activate Pancreatic Stellate Cells in Pancreatic Ductal Adenocarcinoma
por: Li, Na, et al.
Publicado: (2016)

Prognostic Stratification Based on HIF-1 Signaling for Evaluating Hypoxic Status and Immune Infiltration in Pancreatic Ductal Adenocarcinomas
por: Zhuang, Hongkai, et al.
Publicado: (2021)

CA19.9 Response and Tumor Size Predict Recurrence Following Post-neoadjuvant Pancreatectomy in Initially Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma
por: Maggino, Laura, et al.
Publicado: (2022)

An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers
por: Lan, Chungen, et al.
Publicado: (2022)

Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
por: Mohamed, Amal Ahmed, et al.
Publicado: (2019)

Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress
por: She, Chunhua, et al.
Publicado: (2023)

The Influence of MicroRNA-31 on Oxidative Stress and Radiosensitivity in Pancreatic Ductal Adenocarcinoma
por: McGrath, Jason, et al.
Publicado: (2022)

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions
por: Prinz, Christian, et al.
Publicado: (2022)

Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma
por: Tanaka, Takayuki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pkhdkbsta137k9kk1eg84ge27j