Antibody h-R3-dendrimer mediated siRNA has excellent endosomal escape and tumor targeted delivery ability, and represents efficient siPLK1 silencing and inhibition of cell proliferation, migration and invasion

The major obstacle to developing siRNA delivery is their extracellular and intracellular barriers. Herein, a humanized anti-EGFR monoclonal antibody h-R3 was developed to modify the self-assembled binary complexes (dendriplexes) of PAMAM and siRNA via electrostatic interactions, and two common ligan...

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Detalles Bibliográficos
Autores principales: Li, Jun, Liu, Jing, Li, Shengnan, Hao, Yanli, Chen, Lei, Zhang, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924678/
https://www.ncbi.nlm.nih.gov/pubmed/26883109
http://dx.doi.org/10.18632/oncotarget.7368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924678/
https://www.ncbi.nlm.nih.gov/pubmed/26883109
http://dx.doi.org/10.18632/oncotarget.7368

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