Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment

The clinical benefits of a Hedgehog (Hh) inhibitor, LDE225 (NPV-LDE-225, Erismodegib), have been unclear in hematological cancers. Here, we report that LDE225 selectively inhibited migration and adhesion of mantle cell lymphoma (MCL) to bone marrows via very late antigen-4 (VLA-4) mediated inactivat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Han, Chen, Zheng, Neelapu, Sattva S., Romaguera, Jorge, McCarty, Nami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924720/
https://www.ncbi.nlm.nih.gov/pubmed/26885608
http://dx.doi.org/10.18632/oncotarget.7320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924720/
https://www.ncbi.nlm.nih.gov/pubmed/26885608
http://dx.doi.org/10.18632/oncotarget.7320

Ejemplares similares