Cargando…

Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment

The clinical benefits of a Hedgehog (Hh) inhibitor, LDE225 (NPV-LDE-225, Erismodegib), have been unclear in hematological cancers. Here, we report that LDE225 selectively inhibited migration and adhesion of mantle cell lymphoma (MCL) to bone marrows via very late antigen-4 (VLA-4) mediated inactivat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Han, Chen, Zheng, Neelapu, Sattva S., Romaguera, Jorge, McCarty, Nami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924720/ https://www.ncbi.nlm.nih.gov/pubmed/26885608 http://dx.doi.org/10.18632/oncotarget.7320

Ejemplares similares

Nuclear Translocation of B-Cell-Specific Transcription Factor, BACH2, Modulates ROS Mediated Cytotoxic Responses in Mantle Cell Lymphoma
por: Chen, Zheng, et al.
Publicado: (2013)

Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment
por: Rudelius, Martina, et al.
Publicado: (2018)

Targeting Wnt pathway in mantle cell lymphoma-initiating cells
por: Mathur, Rohit, et al.
Publicado: (2015)

Smoldering mantle cell lymphoma
por: Ye, Haige, et al.
Publicado: (2017)

Current trials for frontline therapy of mantle cell lymphoma
por: Steiner, Raphael E., et al.
Publicado: (2018)

Migration and Adhesion of B-Lymphocytes to Specific Microenvironments in Mantle Cell Lymphoma: Interplay between Signaling Pathways and the Epigenetic Landscape
por: Sadeghi, Laia, et al.
Publicado: (2021)

Anti-PD-1 antibodies for the treatment of B-cell lymphoma: Importance of PD-1(+) T-cell subsets
por: Chu, Fuliang, et al.
Publicado: (2014)

ABCG2 is a Direct Transcriptional Target of Hedgehog Signaling and Involved in Stroma-Induced Drug Tolerance in Diffuse Large B-Cell Lymphoma
por: Singh, Rajesh R, et al.
Publicado: (2011)

Spontaneous regression of mantle cell lymphoma: a report of four cases
por: Ye, Haige, et al.
Publicado: (2018)

Tumor Microenvironment and Immunotherapy-Based Approaches in Mantle Cell Lymphoma
por: Saleh, Khalil, et al.
Publicado: (2022)

Therapy of newly diagnosed follicular lymphoma
por: Westin, Jason R., et al.
Publicado: (2012)

Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma
por: Sarkar, Aloke, et al.
Publicado: (2020)

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma
por: Yoshimura, Mariko, et al.
Publicado: (2014)

Therapeutic Vaccine for Lymphoma
por: Lee, Seung-Tae, et al.
Publicado: (2007)

Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report
por: Carulli, Giovanni, et al.
Publicado: (2011)

Paramount therapy for young and fit patients with mantle cell lymphoma: strategies for front-line therapy
por: Ye, Haige, et al.
Publicado: (2018)

CXCR5+CD8+ T cells are localized in B cell follicles and germinal centers and exhibit regulatory and anti-tumor function
por: Chu, Fuliang, et al.
Publicado: (2015)

Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells
por: Sadeghi, Laia, et al.
Publicado: (2020)

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells
por: Body, Simon, et al.
Publicado: (2017)

Influence of microenvironment on cell adhesion, polarization, and migration
por: Pajic-Lijakovic, Ivana, et al.
Publicado: (2012)

Effect of prognostic classification on temsirolimus efficacy and safety in patients with relapsed or refractory mantle cell lymphoma: a retrospective analysis
por: Hess, Georg, et al.
Publicado: (2015)

Uncovering the Bone Marrow Microenvironment Cell by Cell
por: Vinchi, Francesca, et al.
Publicado: (2019)

Impact and Intricacies of Bone Marrow Microenvironment in B-cell Lymphomas: From Biology to Therapy
por: Sircar, Anuvrat, et al.
Publicado: (2020)

Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment
por: Becker, Pamela S.
Publicado: (2012)

P1246: DIFFERENTIAL ROLE OF MICROENVIRONMENT AND STROMAL-CELL INDUCED VENETOCLAX RESISTANCE IN MANTLE CELL LYMPHOMA
por: Andersen, P., et al.
Publicado: (2022)

Evaluating Acalabrutinib In The Treatment Of Mantle Cell Lymphoma: Design, Development, And Place In Therapy
por: Girard, Jennifer, et al.
Publicado: (2019)

Hodgkin Lymphoma Untreated for Six Years Presenting with Tracheoesophageal Fistula
por: Westin, Jason R., et al.
Publicado: (2012)

Primary gastric mantle cell lymphoma
por: Petranovic, Duska, et al.
Publicado: (2012)

Mantle cell lymphoma with skin involvement
por: Kalińska-Bienias, Agnieszka, et al.
Publicado: (2015)

Esophageal location of mantle cell lymphoma
por: Michopoulos, Spyros
Publicado: (2016)

Tracheobronchial involvement of mantle cell lymphoma
por: Tong, Lin, et al.
Publicado: (2018)

Mantle Cell Lymphoma Case Report
por: Podzolkov, V.I., et al.
Publicado: (2018)

Educational Case: Mantle Cell Lymphoma
por: Mai, Brenda, et al.
Publicado: (2020)

Emerging therapies in mantle cell lymphoma
por: Hanel, Walter, et al.
Publicado: (2020)

Tackling Mantle Cell Lymphoma in Europe
por: Horgan, Denis, et al.
Publicado: (2022)

CAR T-cell therapy for follicular lymphoma and mantle cell lymphoma
por: Mohty, Razan, et al.
Publicado: (2022)

Mantle Cell Lymphoma of Mucosa-Associated Lymphoid Tissue: A European Mantle Cell Lymphoma Network Study
por: Morello, Lucia, et al.
Publicado: (2019)

Editorial: CAR T-Cell Therapies in Hematologic Tumors
por: Coscia, Marta, et al.
Publicado: (2020)

Mantle cell lymphoma with features of marginal-zone lymphoma
por: Randen, Ulla, et al.
Publicado: (2011)

De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly
por: Elyamany, Ghaleb, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8galfg8grs4d4g1622bd5qhoot