Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3

PP2C family serine/threonine phosphatase WIP1 acts as a negative regulator of the tumor suppressor p53 and is implicated in silencing of cellular responses to genotoxic stress. Chromosomal locus 17q23 carrying the PPM1D (coding for WIP1) is commonly amplified in breast carcinomas and WIP1 was propos...

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Detalles Bibliográficos
Autores principales: Pechackova, Sona, Burdova, Kamila, Benada, Jan, Kleiblova, Petra, Jenikova, Gabriela, Macurek, Libor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924728/
https://www.ncbi.nlm.nih.gov/pubmed/26883108
http://dx.doi.org/10.18632/oncotarget.7363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924728/
https://www.ncbi.nlm.nih.gov/pubmed/26883108
http://dx.doi.org/10.18632/oncotarget.7363

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