Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells

Obatoclax, a pan-inhibitor of anti-apoptotic Bcl-2 proteins, exhibits cytotoxic effect on cancer cells through both apoptosis-dependent and -independent pathways. Here we show that obatoclax caused cytotoxicity in both cisplatin-sensitive and -resistant esophageal cancer cells. Although obatoclax sh...

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Detalles Bibliográficos
Autores principales: Yu, Le, Wu, William KK, Gu, Chunping, Zhong, Desheng, Zhao, Xuyan, Kong, Yi, Lin, Qinghuan, Chan, Matthew TV, Zhou, Zhitao, Liu, Shuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924745/
https://www.ncbi.nlm.nih.gov/pubmed/26910910
http://dx.doi.org/10.18632/oncotarget.7492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924745/
https://www.ncbi.nlm.nih.gov/pubmed/26910910
http://dx.doi.org/10.18632/oncotarget.7492

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