Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells

Interference with telomerase and telomere maintenance is emerging as an attractive target for anticancer therapies. Ligand-induced stabilization of G-quadruplex formation by the telomeric DNA 3′-overhang inhibits telomerase from catalyzing telomeric DNA synthesis and from capping telomeric ends, mak...

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Detalles Bibliográficos
Autores principales: Zhou, Guangtong, Liu, Xinrui, Li, Yunqian, Xu, Songbai, Ma, Chengyuan, Wu, Xinmin, Cheng, Ye, Yu, Zhiyun, Zhao, Gang, Chen, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924762/
https://www.ncbi.nlm.nih.gov/pubmed/26908447
http://dx.doi.org/10.18632/oncotarget.7483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924762/
https://www.ncbi.nlm.nih.gov/pubmed/26908447
http://dx.doi.org/10.18632/oncotarget.7483

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