An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells

Glycogen synthase kinase (GSK)-3β facilitates interferon (IFN)-γ signaling by inhibiting Src homology-2 domain-containing phosphatase (SHP) 2. Mutated phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) cause AKT activation and GSK-3β inactivation to induce SHP2-activated cell...

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Detalles Bibliográficos
Autores principales: Tseng, Po-Chun, Chen, Chia-Ling, Shan, Yan-Shen, Lin, Chiou-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924776/
https://www.ncbi.nlm.nih.gov/pubmed/26934444
http://dx.doi.org/10.18632/oncotarget.7750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924776/
https://www.ncbi.nlm.nih.gov/pubmed/26934444
http://dx.doi.org/10.18632/oncotarget.7750

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