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A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization

The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization and function in the transport of bile acids and ot...

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Detalles Bibliográficos
Autores principales: Xu, Shuhua, Soroka, Carol J., Sun, An-Qiang, Backos, Donald S., Mennone, Albert, Suchy, Frederick J., Boyer, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924846/
https://www.ncbi.nlm.nih.gov/pubmed/27351185
http://dx.doi.org/10.1371/journal.pone.0158269