The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

BACKGROUND: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the effects of the novel HDAC inhibitor (HDACi) panobinostat, both alone and in comb...

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Detalles Bibliográficos
Autores principales: Helland, Øystein, Popa, Mihaela, Bischof, Katharina, Gjertsen, Bjørn Tore, McCormack, Emmet, Bjørge, Line
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924861/
https://www.ncbi.nlm.nih.gov/pubmed/27352023
http://dx.doi.org/10.1371/journal.pone.0158208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924861/
https://www.ncbi.nlm.nih.gov/pubmed/27352023
http://dx.doi.org/10.1371/journal.pone.0158208

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