Targeting MTHFD2 in acute myeloid leukemia

Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2), emerged as a top candidate in our an...

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Detalles Bibliográficos
Autores principales: Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline A., Ramos, Azucena, Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Hemann, Michael T., Vander Heiden, Matthew G., Banerji, Versha, Stegmaier, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925018/
https://www.ncbi.nlm.nih.gov/pubmed/27325891
http://dx.doi.org/10.1084/jem.20151574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925018/
https://www.ncbi.nlm.nih.gov/pubmed/27325891
http://dx.doi.org/10.1084/jem.20151574

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