Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization

Clonal anergy is an enigmatic self-tolerance mechanism because no apparent purpose is served by retaining functionally silenced B cells bearing autoantibodies. Human autoantibodies with IGHV4-34*01 heavy chains bind to poly-N-acetyllactosamine carbohydrates (I/i antigen) on erythrocytes and B lympho...

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Detalles Bibliográficos
Autores principales: Reed, Joanne H., Jackson, Jennifer, Christ, Daniel, Goodnow, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925023/
https://www.ncbi.nlm.nih.gov/pubmed/27298445
http://dx.doi.org/10.1084/jem.20151978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925023/
https://www.ncbi.nlm.nih.gov/pubmed/27298445
http://dx.doi.org/10.1084/jem.20151978

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