Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Adoptive transfer of peripheral blood–derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a...

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Detalles Bibliográficos
Autores principales: Chapuis, Aude G., Lee, Sylvia M., Thompson, John A., Roberts, Ilana M., Margolin, Kim A., Bhatia, Shailender, Sloan, Heather L., Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D., Greenberg, Philip D., Yee, Cassian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925025/
https://www.ncbi.nlm.nih.gov/pubmed/27242164
http://dx.doi.org/10.1084/jem.20152021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925025/
https://www.ncbi.nlm.nih.gov/pubmed/27242164
http://dx.doi.org/10.1084/jem.20152021

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